| http://purl.uniprot.org/citations/29140246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29140246 | http://www.w3.org/2000/01/rdf-schema#comment | "Craniofacial morphogenesis requires proper development of pharyngeal arches and epibranchial placodes. We show that the epibranchial placodes, in addition to giving rise to cranial sensory neurons, generate a novel lineage-related non-neuronal cell population for mouse pharyngeal arch development. Eya1 is essential for the development of epibranchial placodes and proximal pharyngeal arches. We identify an Eya1-Notch regulatory axis that specifies both the neuronal and non-neuronal commitment of the epibranchial placode, where Notch acts downstream of Eya1 and promotes the non-neuronal cell fate. Notch is regulated by the threonine phosphatase activity of Eya1. Eya1 dephosphorylates p-threonine-2122 of the Notch1 intracellular domain (Notch1 ICD), which increases the stability of Notch1 ICD and maintains Notch signaling activity in the non-neuronal epibranchial placodal cells. Our data unveil a more complex differentiation program in epibranchial placodes and an important role for the Eya1-Notch axis in craniofacial morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.30126"xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Wong E.Y.M."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Lendahl U."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Sham M.H."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Xu P.X."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/author | "Tsang S.L."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/pages | "e30126"xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/title | "An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/29140246 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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