| http://purl.uniprot.org/citations/29141217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29141217 | http://www.w3.org/2000/01/rdf-schema#comment | "Effector T cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental Plasmodium infection and are believed to be critical for resistance to clinical malaria. To determine whether Plasmodium-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 T cells in experimental models. We found that populations of both Th1- and Tfh-like Plasmodium-specific memory CD4 T cells persist. Unexpectedly, Th1-like memory cells exhibit phenotypic and functional features of Tfh cells during recall and provide potent B cell help and protection following transfer, characteristics that are enhanced following ligation of the T cell co-stimulatory receptor OX40. Our findings delineate critical functional attributes of Plasmodium-specific memory CD4 T cells and identify a host-specific factor that can be targeted to improve resolution of acute malaria and provide durable, long-term protection against Plasmodium parasite re-exposure."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.10.077"xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Kappe S.H.I."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Lindner S.E."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Vaughan A.M."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Graham A.C."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Vijay R."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Guthmiller J.J."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Butler N.S."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Zander R.A."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/author | "Pack A.D."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/pages | "1839-1852"xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/title | "Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity."xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/29141217 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29141217 |
| http://purl.uniprot.org/citations/29141217 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29141217 |
| http://purl.uniprot.org/uniprot/#_P01849-mappedCitation-29141217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29141217 |
| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-29141217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29141217 |
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| http://purl.uniprot.org/uniprot/#_Q3TR87-mappedCitation-29141217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29141217 |
| http://purl.uniprot.org/uniprot/#_Q9JKD8-mappedCitation-29141217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29141217 |
| http://purl.uniprot.org/uniprot/#_Q8C2F3-mappedCitation-29141217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29141217 |