| http://purl.uniprot.org/citations/29142196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29142196 | http://www.w3.org/2000/01/rdf-schema#comment | "Receptor activator of NF-kB ligand (RANKL) generates intracellular reactive oxygen species (ROS), which increase RANKL-mediated signaling in osteoclast (OC) precursor bone marrow macrophages (BMMs). Here we show that a ROS scavenging protein DJ-1 negatively regulates RANKL-driven OC differentiation, also called osteoclastogenesis. DJ-1 ablation in mice leads to a decreased bone volume and an increase in OC numbers. In vitro, the activation of RANK-dependent signals is enhanced in DJ-1-deficient BMMs as compared to wild-type BMMs. DJ-1 suppresses the activation of both RANK-TRAF6 and RANK-FcRγ/Syk signaling pathways because of activation of Src homology region 2 domain-containing phosphatase-1, which is inhibited by ROS. Ablation of DJ-1 in mouse models of arthritis and RANKL-induced bone disease leads to an increase in the number of OCs, and exacerbation of bone damage. Overall, our results suggest that DJ-1 plays a role in bone homeostasis in normal physiology and in bone-associated pathology by negatively regulating osteoclastogenesis."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01527-y"xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Lee S.K."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Park Y.H."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Kim H.W."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Park Y.M."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Choi W.S."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Won K.J."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Beaven M.A."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Nam S.T."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Kim H.S.'"xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/author | "Mun S.H."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/pages | "1519"xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/title | "DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation."xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29142196 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29142196 |
| http://purl.uniprot.org/citations/29142196 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29142196 |
| http://purl.uniprot.org/uniprot/#_D3K2X3-mappedCitation-29142196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29142196 |