| http://purl.uniprot.org/citations/29144446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29144446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29144446 | http://www.w3.org/2000/01/rdf-schema#comment | "Ebola and Marburg viruses are filoviruses: filamentous, enveloped viruses that cause haemorrhagic fever. Filoviruses are within the order Mononegavirales, which also includes rabies virus, measles virus, and respiratory syncytial virus. Mononegaviruses have non-segmented, single-stranded negative-sense RNA genomes that are encapsidated by nucleoprotein and other viral proteins to form a helical nucleocapsid. The nucleocapsid acts as a scaffold for virus assembly and as a template for genome transcription and replication. Insights into nucleoprotein-nucleoprotein interactions have been derived from structural studies of oligomerized, RNA-encapsidating nucleoprotein, and cryo-electron microscopy of nucleocapsid or nucleocapsid-like structures. There have been no high-resolution reconstructions of complete mononegavirus nucleocapsids. Here we apply cryo-electron tomography and subtomogram averaging to determine the structure of Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies. These structures reveal the identity and arrangement of the nucleocapsid components, and suggest that the formation of an extended α-helix from the disordered carboxy-terminal region of nucleoprotein-core links nucleoprotein oligomerization, nucleocapsid condensation, RNA encapsidation, and accessory protein recruitment."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature24490"xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature24490"xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Becker S."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Becker S."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Clarke M."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Clarke M."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Noda T."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Noda T."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Kolesnikova L."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Kolesnikova L."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Briggs J.A.G."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Briggs J.A.G."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Koehler A."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Koehler A."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Wan W."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/author | "Wan W."xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/pages | "394-397"xsd:string |
| http://purl.uniprot.org/citations/29144446 | http://purl.uniprot.org/core/pages | "394-397"xsd:string |