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http://purl.uniprot.org/citations/29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29144828http://www.w3.org/2000/01/rdf-schema#comment"This study aimed to determine the prognostic impact of CD200 and CD56 expression in pediatric B cell acute lymphoblastic leukemia (B-ALL) patients, both of which have been implicated in immune tolerance and previously suggested as independent risk factors. CD200 has a central role in immune tolerance that protects stem cells and other critical tissues from immune damage. The expression of CD200/CD56 in leukemic blasts were assessed in leukemic blasts before chemotherapy in 43 bone marrow (BM) and/or peripheral blood (PB) samples by flow cytometry. Twenty eight of 43 B-ALL cases (65%) showed CD200 positive expression, 5 of 43 cases (11.6%) showed CD56 expression, and only 2 patients (4.7%) expressed both CD200 and CD56. Patients with CD200+ and CD56+ were significantly associated with lower platelet count; less tendency for induction of remission response as compared to negative ones (p = .01 for both). The overall survival (OS) and DFS were significantly shorter in CD200+ and CD56+ cases as compared to those with CD200- and CD56- expression. In conclusion, CD200 and/or CD56 positive expression in B-ALL at diagnosis suggest a poor prognosis and may be associated with biological aggressiveness."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.org/dc/terms/identifier"doi:10.1080/08880018.2017.1363836"xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/author"Ibrahim L."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/author"Aref S."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/author"Abdel Aziz S."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/author"Azmy E."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/author"El-Bakry K."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/name"Pediatr Hematol Oncol"xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/pages"275-285"xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/title"Prognostic impact of CD200 and CD56 expression in pediatric B-cell acute lymphoblastic leukemia patients."xsd:string
http://purl.uniprot.org/citations/29144828http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/29144828http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29144828
http://purl.uniprot.org/citations/29144828http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29144828
http://purl.uniprot.org/uniprot/#_A0A0C4DGS4-mappedCitation-29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/#_A0A087WWD4-mappedCitation-29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/#_B4DSQ7-mappedCitation-29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/#_B7Z8D6-mappedCitation-29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/#_P13591-mappedCitation-29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/#_O00557-mappedCitation-29144828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/A0A0C4DGS4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/P13591http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/A0A087WWD4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29144828
http://purl.uniprot.org/uniprot/O00557http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29144828