http://purl.uniprot.org/citations/29144828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/29144828 | http://www.w3.org/2000/01/rdf-schema#comment | "This study aimed to determine the prognostic impact of CD200 and CD56 expression in pediatric B cell acute lymphoblastic leukemia (B-ALL) patients, both of which have been implicated in immune tolerance and previously suggested as independent risk factors. CD200 has a central role in immune tolerance that protects stem cells and other critical tissues from immune damage. The expression of CD200/CD56 in leukemic blasts were assessed in leukemic blasts before chemotherapy in 43 bone marrow (BM) and/or peripheral blood (PB) samples by flow cytometry. Twenty eight of 43 B-ALL cases (65%) showed CD200 positive expression, 5 of 43 cases (11.6%) showed CD56 expression, and only 2 patients (4.7%) expressed both CD200 and CD56. Patients with CD200+ and CD56+ were significantly associated with lower platelet count; less tendency for induction of remission response as compared to negative ones (p = .01 for both). The overall survival (OS) and DFS were significantly shorter in CD200+ and CD56+ cases as compared to those with CD200- and CD56- expression. In conclusion, CD200 and/or CD56 positive expression in B-ALL at diagnosis suggest a poor prognosis and may be associated with biological aggressiveness."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.org/dc/terms/identifier | "doi:10.1080/08880018.2017.1363836"xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/author | "Ibrahim L."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/author | "Aref S."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/author | "Abdel Aziz S."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/author | "Azmy E."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/author | "El-Bakry K."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/name | "Pediatr Hematol Oncol"xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/pages | "275-285"xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/title | "Prognostic impact of CD200 and CD56 expression in pediatric B-cell acute lymphoblastic leukemia patients."xsd:string |
http://purl.uniprot.org/citations/29144828 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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