| http://purl.uniprot.org/citations/29158485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29158485 | http://www.w3.org/2000/01/rdf-schema#comment | "Degradation of maternal proteins by the ubiquitin-proteasome system (UPS) accompanies the maternal-to-zygotic transition. DPPA3/Stella/PGC7, encoded by a maternal effect gene, is present in the nucleus and cytoplasm of zygotes and has been associated with protecting the female pronucleus from TET3-mediated demethylation. We now report that cytoplasmic DPPA3 is partially cleaved by the ubiquitin-proteasome system and an N-terminus fragment remains in the cytoplasm where it associates with early and re-cycling endosomes. If DPPA3 is absent or if cleavage is prevented, multiple vesicles coalesce/aggregate and markers of lysosomes are decreased. Fertilized eggs develop poorly into blastocysts, which results in significantly decreased fecundity of Dppa3 R60A transgenic mice. This phenocopies aspects of Lamp1/2 knockdowns and Dppa3 KO embryos can be partially rescued in vitro by DPPA31-60 and to a lesser extent by LAMP1/2. Thus, the N-terminus of DPPA3 has a significant role in cytoplasmic vesicular trafficking in addition to its previously reported nuclear function."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01387-6"xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/author | "Baibakov B."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/author | "Dean J."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/author | "Jimenez-Movilla M."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/author | "Shin S.W."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/author | "Vogt E.J."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/pages | "1643"xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/title | "Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice."xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29158485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29158485 |
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