| http://purl.uniprot.org/citations/29161354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29161354 | http://www.w3.org/2000/01/rdf-schema#comment | "The neuronal scaffold protein p140Cap was investigated during hippocampal network formation. p140Cap is present in presynaptic GABAergic terminals and its genetic depletion results in a marked alteration of inhibitory synaptic activity. p140Cap-/-cultured neurons display higher frequency of miniature inhibitory postsynaptic currents (mIPSCs) with no changes of their mean amplitude. Consistent with a potential presynaptic alteration of basal GABA release, p140Cap-/-neurons exhibit a larger synaptic vesicle readily releasable pool, without any variation of single GABAA receptor unitary currents and number of postsynaptic channels. Furthermore, p140Cap-/-neurons show a premature and enhanced network synchronization and appear more susceptible to 4-aminopyridine-induced seizures in vitro and to kainate-induced seizures in vivo. The hippocampus of p140Cap-/-mice showed a significant increase in the number of both inhibitory synapses and of parvalbumin- and somatostatin-expressing interneurons. Specific deletion of p140Cap in forebrain interneurons resulted in increased susceptibility to in vitro epileptic events and increased inhibitory synaptogenesis, comparable to those observed in p140Cap-/-mice. Altogether, our data demonstrate that p140Cap finely tunes inhibitory synaptogenesis and GABAergic neurotransmission, thus regulating the establishment and maintenance of the proper hippocampal excitatory/inhibitory balance."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhx306"xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Russo I."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Giustetto M."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Angelini C."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Alfieri A."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Turco E."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Carbone E."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Defilippi P."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Matteoli M."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Menna E."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Sassoe-Pognetto M."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Taverna S."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Corradini I."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Carabelli V."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Marcantoni A."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Morello N."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Vandael D."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Bianchi F.T."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Gavello D."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Focchi E."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Yekhlef L."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Morellato A."xsd:string |
| http://purl.uniprot.org/citations/29161354 | http://purl.uniprot.org/core/author | "Ottaviani M.M."xsd:string |