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http://purl.uniprot.org/citations/29161980http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29161980http://www.w3.org/2000/01/rdf-schema#comment"

Background

The aim of the study is to determine the prognostic relevance of CD200/ CD56 expression in adult acute lymphoblastic leukemia patients.

Methods

The expression of CD200 and CD56 by blast cells was assessed by flow cytometry before the start of chemotherapy in 70 B-ALL patients.

Results

Positive expression of CD200 was detected in forty-six patients (66%) and CD56 was detected in 7 patients (10%) out of 70 patients, respectively. Only three patients (4.3%) had co-expression for CD200+ and CD56+. Splenomegaly and thrombocytopenia were frequently observed more in CD200+ patients. Increased frequency of CD34+ was associated with CD200+and CD56+ patients. The CD200+ and CD56+ subgroups of B-ALL patients had inferior OS and disease free survival compared to CD 200- and CD 56- patients.

Conclusions

CD200+ and/or CD56+ positive expression in B-ALL patients at diagnosis is a poor prognostic biomarker. Identification of CD200+ and CD56+ expression at diagnosis is recommended for a better stratification of adult B-ALL patients."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.org/dc/terms/identifier"doi:10.1080/10245332.2017.1404276"xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/author"Ibrahim L."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/author"Aref S."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/author"Mabed M."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/author"Azmy E."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/author"El-Bakry K."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/name"Hematology"xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/pages"263-270"xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/title"Prognostic impact of CD200 and CD56 expression in adult acute lymphoblastic leukemia patients."xsd:string
http://purl.uniprot.org/citations/29161980http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/29161980http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29161980
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http://purl.uniprot.org/uniprot/#_O00557-mappedCitation-29161980http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29161980
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