| http://purl.uniprot.org/citations/29166609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29166609 | http://www.w3.org/2000/01/rdf-schema#comment | "A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.10.083"xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Martinez J."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Pineda E."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Marin M."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Prat A."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Piao X."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Alonso M.M."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Nakano I."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Mira H."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "de la Iglesia N."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Bhat K.P."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Moreno M."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Gomez-Manzano C."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Sulman E.P."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Graus F."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Pedrosa L."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Tortosa A."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Conroy S."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Herreros A."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Ribalta T."xsd:string |
| http://purl.uniprot.org/citations/29166609 | http://purl.uniprot.org/core/author | "Balasubramaniyan V."xsd:string |