| http://purl.uniprot.org/citations/29170386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29170386 | http://www.w3.org/2000/01/rdf-schema#comment | "The glucocorticoid (GC) receptor (GR) suppresses inflammation by activating anti-inflammatory and repressing pro-inflammatory genes. GR-interacting protein-1 (GRIP1) is a GR corepressor in macrophages, however, whether GRIP1 mediates GR-activated transcription, and what dictates its coactivator versus corepressor properties is unknown. Here we report that GRIP1 loss in macrophages attenuates glucocorticoid induction of several anti-inflammatory targets, and that GC treatment of quiescent macrophages globally directs GRIP1 toward GR binding sites dominated by palindromic GC response elements (GRE), suggesting a non-redundant GRIP1 function as a GR coactivator. Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Phosphorylation potentiates GRIP1 coactivator but, remarkably, not its corepressor properties. Consistently, phospho-GRIP1 and CDK9 are not detected at GR transrepression sites near pro-inflammatory genes. Thus, GR restricts actions of its own coregulator via CDK9-mediated phosphorylation to a subset of anti-inflammatory genes."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01569-2"xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Fisher R.P."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Rogatsky I."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Pufall M.A."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Chinenov Y."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Kharlyngdoh J.B."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Coppo M."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Sacta M.A."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Mimouna S."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Rollins D.A."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/author | "Tharmalingam B."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/pages | "1739"xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/title | "Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages."xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29170386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29170386 |
| http://purl.uniprot.org/citations/29170386 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29170386 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-29170386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29170386 |
| http://purl.uniprot.org/uniprot/#_D3YWY4-mappedCitation-29170386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29170386 |
| http://purl.uniprot.org/uniprot/#_A0A571BG81-mappedCitation-29170386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29170386 |