Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/29174965http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29174965http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29174965http://www.w3.org/2000/01/rdf-schema#comment"

Objective

New tests for diagnosing active tuberculosis (aTB) are urgently needed, and TB antigen-specific cell-mediated immunity can be expected to develop new testing methods of aTB.

Materials and methods

Rv0183 protein, the only monoglyceride lipase identified in mycobacteria, was used to stimulate freshly heparin-treated whole blood. The Rv0183-specific cytokines/chemokines response associated with aTB was screened firstly with 4 aTB patients and 4 LTBIs, and further evaluated in 192 suspected aTB patients and 372 healthy individuals.

Results

Out of 71 cytokines/chemokines, the response of IL-6 against Rv0183 protein was found to be associated with aTB. The Rv0183-specific IL-6 response was significantly higher in aTB patients (n = 128) than in those with non-TB lung disease (n = 64) and in healthy individuals (n = 327) (p < 0.0001), and not affected by latent TB infection. In IGRA+ suspected active TB patients, the sensitivity, specificity, PPV and NPV of IL-6 response (with cutoff of 235.2 pg/ml) were 85.7%, 100%, 100% and 51.5% for diagnosing aTB, respectively. While in IGRA-ones, they were 87.5%, 80.5%, 60.9% and 95.0% with 174.2 pg/ml IL-6 response as cutoff, respectively.

Conclusions

These results clearly show that the Rv0183 antigen-specific IL-6 response has the potential to be used as an immune-diagnosis test for active TB in clinical practice."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.org/dc/terms/identifier"doi:10.1016/j.jinf.2017.11.004"xsd:string
http://purl.uniprot.org/citations/29174965http://purl.org/dc/terms/identifier"doi:10.1016/j.jinf.2017.11.004"xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Liu W."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Liu W."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Liu Y.'"xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Liu Y.'"xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Xia N."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Xia N."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Zhong Z."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Zhong Z."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Ge S."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/author"Ge S."xsd:string
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29174965http://purl.uniprot.org/core/date"2018"xsd:gYear
▶