| http://purl.uniprot.org/citations/29178930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29178930 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model.ResultsThe DNA mismatch repair proteins are members of the ABC family of ATPases. ATP binding and hydrolysis regulates their mismatch repair function. In the current study, a mouse model was generated harboring a glycine to aspartic acid residue change in the Walker A motif of the ATPase domain of Msh3. Impaired ATP mediated release of the Msh2-Msh3 GD/GD complex from it's DNA substrate in vitro confirmed the presence of an ATPase defect. However, the mismatch repair function of the protein was not significantly affected. Therefore, mutation of a critical residue within the ATPase domain of Msh3 did not preclude mismatch repair at the genomic sequences tested. Indicating that Msh3 mediated mismatch function is retained the absence of a functional ATPase domain."xsd:string |
| http://purl.uniprot.org/citations/29178930 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13104-017-2939-4"xsd:string |
| http://purl.uniprot.org/citations/29178930 | http://purl.uniprot.org/core/author | "Edwards Y."xsd:string |
| http://purl.uniprot.org/citations/29178930 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29178930 | http://purl.uniprot.org/core/name | "BMC Res Notes"xsd:string |
| http://purl.uniprot.org/citations/29178930 | http://purl.uniprot.org/core/pages | "616"xsd:string |
| http://purl.uniprot.org/citations/29178930 | http://purl.uniprot.org/core/title | "An Msh3 ATPase domain mutation has no effect on MMR function."xsd:string |
| http://purl.uniprot.org/citations/29178930 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q62156-mappedCitation-29178930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29178930 |
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