| http://purl.uniprot.org/citations/29178985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29178985 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-suppressing subchromosomal transferable fragment cDNA 6 (TSSC6) expression is restricted to hematopoietic organs and tissues where it plays a role in hematopoietic-cell function. The ADP purinergic receptor P2Y12 is mainly expressed by platelets with important clinical significance as a target for several clinically approved antithrombotic agents. We have previously shown a physical association between P2Y12 and TSSC6 in platelets. Hence our aim was to investigate whether this physical association is translated to functional effects. To investigate this possibility, we used wild-type or TSSC6 knockout (KO) mice treated with either PBS or 50mg/kg clopidogrel. TSSC6 KO mice treated with clopidogrel exhibited synergy in delayed kinetics of clot retraction, reduced collagen-mediated platelet aggregation, and platelet spreading on fibrinogen. Platelets derived from TSSC6 mice with P2Y12 blockade form smaller thrombi when perfused over a collagen matrix under arterial flow. Clopidogrel treated TSSC6 KO arterioles showed smaller and less stable thrombi with increased tendency to embolise in vivo. These studies demonstrate a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin αIIbβ3 signalling thrombus growth and stability."xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.thromres.2017.11.009"xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/author | "Wright M.D."xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/author | "Jackson D.E."xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/author | "Howells D."xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/author | "Makkawi M."xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/name | "Thromb Res"xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/pages | "12-21"xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/title | "A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y12 receptor in platelets."xsd:string |
| http://purl.uniprot.org/citations/29178985 | http://purl.uniprot.org/core/volume | "161"xsd:string |
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