| http://purl.uniprot.org/citations/29179998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29179998 | http://www.w3.org/2000/01/rdf-schema#comment | "ELL2 is an androgen-responsive gene that is expressed by prostate epithelial cells and is frequently down-regulated in prostate cancer. Deletion of Ell2 in the murine prostate induced murine prostatic intraepithelial neoplasia and ELL2 knockdown enhanced proliferation and migration in C4-2 prostate cancer cells. Here, knockdown of ELL2 sensitized prostate cancer cells to DNA damage and overexpression of ELL2 protected prostate cancer cells from DNA damage. Knockdown of ELL2 impaired non-homologous end joining repair but not homologous recombination repair. Transfected ELL2 co-immunoprecipitated with both Ku70 and Ku80 proteins. ELL2 could bind to and co-accumulate with Ku70/Ku80 proteins at sites of DNA damage. Knockdown of ELL2 dramatically inhibited Ku70 and Ku80 recruitment and retention at DNA double-strand break sites in prostate cancer cells. The impaired recruitment of Ku70 and Ku80 proteins to DNA damage sites upon ELL2 knockdown was rescued by re-expression of an ELL2 transgene insensitive to siELL2. This study suggests that ELL2 is required for efficient NHEJ repair via Ku70/Ku80 in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2017.11.028"xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Lan L."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Shan Y."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Wei L."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Qiu X."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Zhong M."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Xue B."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Nelson J.B."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Ai J."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Zang Y."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/author | "Pascal L.E."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/pages | "198-207"xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/title | "ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://purl.uniprot.org/core/volume | "415"xsd:string |
| http://purl.uniprot.org/citations/29179998 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29179998 |
| http://purl.uniprot.org/citations/29179998 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29179998 |
| http://purl.uniprot.org/uniprot/#_B4DTQ1-mappedCitation-29179998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29179998 |