| http://purl.uniprot.org/citations/29180440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29180440 | http://www.w3.org/2000/01/rdf-schema#comment | "As the outermost physical barrier of an organism, the skin is diurnally exposed to UV radiation (UVR). Recent studies have revealed that the skin exhibits a circadian rhythm in various functions, and this oscillation is disturbed and reset via a strong environmental cue, the UVR. However, a molecular link between circadian perturbation by UVR and UVR-induced cellular responses has not been investigated. We identified tissue inhibitor of metalloproteinase ( TIMP)-3 as a novel circadian locomotor output cycles kaput (CLOCK)-dependent diurnal gene by using a CLOCK-knockdown strategy in human keratinocytes. Among dozens of identified transcripts down-regulated by CLOCK knockdown, TIMP3 displayed a rhythmic expression in a CLOCK-dependent manner, in which the expression of matrix metalloproteinase (MMP)-1 and inflammatory cytokines, such as TNF-α, chemokine (C-X-C motif) ligand (CXCL)-1, and IL-8, were inversely regulated. Upon UVB exposure, the expression of CLOCK and TIMP3 was down-regulated, which led to an up-regulation of secretion of MMP1 and TNF-α proteins and in the transcription of CXCL1 and IL-8 via CCAAT-enhancer binding protein (C/EBP)-α. UVB-induced TNF-α secretion increased further or decreased by knockdown or overexpression of TIMP3, respectively, as well as by CLOCK. As a novel CLOCK-dependent diurnal gene, TIMP3 inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes. Thus, our work suggests a molecular link between circadian perturbation by UVR and UVR-induced inflammation.-Park, S., Kim, K., Bae, I.-H., Lee, S. H., Jung, J., Lee, T. R., Cho, E.-G. TIMP3 is a CLOCK-dependent diurnal gene that inhibits the expression of UVB-induced inflammatory cytokines in human keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.201700693r"xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Lee T.R."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Cho E.G."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/author | "Bae I.H."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/pages | "1510-1523"xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/title | "TIMP3 is a CLOCK-dependent diurnal gene that inhibits the expression of UVB-induced inflammatory cytokines in human keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/29180440 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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