| http://purl.uniprot.org/citations/29180744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29180744 | http://www.w3.org/2000/01/rdf-schema#comment | "Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2-cells in a paracrine manner. Here, we uncover the mechanisms underlying this paracrine tumourigenesis. We show that expression of oncogenic β-catenin in Hesx1+ embryonic precursors also results in stem cell clusters and paracrine tumours. We reveal that human and mouse clusters are analogous and share a common signature of senescence and SASP. Finally, we show that mice with reduced senescence and SASP responses exhibit decreased tumour-inducing potential. Together, we provide evidence that senescence and a stem cell-associated SASP drive cell transformation and tumour initiation in vivo in an age-dependent fashion."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01992-5"xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Rashid M."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Goding C.R."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Andoniadou C.L."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Martinez-Barbera J.P."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Mousavy-Gharavy S.N."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Gil J."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Guerrero A."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Jacques T.S."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Pozzi S."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Kaushal G."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Jani N."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Virasami A."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Carreno G."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Apps J.R."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Panousopoulos L."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Stache C."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Gonzalez-Meljem J.M."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/author | "Haston S."xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29180744 | http://purl.uniprot.org/core/pages | "1819"xsd:string |