| http://purl.uniprot.org/citations/29183982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29183982 | http://www.w3.org/2000/01/rdf-schema#comment | "Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this approach generally suffers from low consistency between screens. We found that many SS/L interactions involve essential genes and are therefore detectable within a limited range of knockdown efficiency. Such interactions are often missed by overly efficient RNAi reagents. We therefore developed an assay that measures viability over a range of knockdown efficiency within a cell population. This method, called Variable Dose Analysis (VDA), is highly sensitive to viability phenotypes and reproducibly detects SS/L interactions. We applied the VDA method to search for SS/L interactions with TSC1 and TSC2, the two tumor suppressors underlying tuberous sclerosis complex (TSC), and generated a SS/L network for TSC. Using this network, we identified four Food and Drug Administration-approved drugs that selectively affect viability of TSC-deficient cells, representing promising candidates for repurposing to treat TSC-related tumors."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1713362114"xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Kelley C."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Perrimon N."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Manning B.D."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Housden B.E."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/author | "Valvezan A.J."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/pages | "E10755-E10762"xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/title | "Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)."xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/29183982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29183982 |
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| http://purl.uniprot.org/uniprot/#_A1ZAH8-mappedCitation-29183982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29183982 |
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