| http://purl.uniprot.org/citations/29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29187734 | http://www.w3.org/2000/01/rdf-schema#comment | "O-linked N-acetylglucosamine (O-GlcNAc) transferase (Ogt) catalyzes O-GlcNAc modification. O-GlcNAcylation is increased after cross-linking of the B-cell receptor (BCR), but the physiological function of this reaction is unknown. Here we show that lack of Ogt in B-cell development not only causes severe defects in the activation of BCR signaling, but also perturbs B-cell homeostasis by enhancing apoptosis of mature B cells, partly as a result of impaired response to B-cell activating factor. O-GlcNAcylation of Lyn at serine 19 is crucial for efficient Lyn activation and Syk interaction in BCR-mediated B-cell activation and expansion. Ogt deficiency in germinal center (GC) B cells also results in enhanced apoptosis of GC B cells and memory B cells in an immune response, consequently causing a reduction of antibody levels. Together, these results demonstrate that B cells rely on O-GlcNAcylation to maintain homeostasis, transduce BCR-mediated activation signals and activate humoral immunity."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01677-z"xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Wu J.L."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Chiang M.F."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Wang Y.H."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Hsu P.H."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Angata T."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Hung K.H."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Lin K.I."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/author | "Tsai D.Y."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/pages | "1854"xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/title | "O-GlcNAcylation is required for B cell homeostasis and antibody responses."xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29187734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29187734 |
| http://purl.uniprot.org/citations/29187734 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29187734 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR2-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P4-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |
| http://purl.uniprot.org/uniprot/#_Q3U1A5-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |
| http://purl.uniprot.org/uniprot/#_P25918-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |
| http://purl.uniprot.org/uniprot/#_Q8CGY8-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |
| http://purl.uniprot.org/uniprot/#_P01869-mappedCitation-29187734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29187734 |