| http://purl.uniprot.org/citations/29190287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29190287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29190287 | http://www.w3.org/2000/01/rdf-schema#comment | "A large number of SARS-related coronaviruses (SARSr-CoV) have been detected in horseshoe bats since 2005 in different areas of China. However, these bat SARSr-CoVs show sequence differences from SARS coronavirus (SARS-CoV) in different genes (S, ORF8, ORF3, etc) and are considered unlikely to represent the direct progenitor of SARS-CoV. Herein, we report the findings of our 5-year surveillance of SARSr-CoVs in a cave inhabited by multiple species of horseshoe bats in Yunnan Province, China. The full-length genomes of 11 newly discovered SARSr-CoV strains, together with our previous findings, reveals that the SARSr-CoVs circulating in this single location are highly diverse in the S gene, ORF3 and ORF8. Importantly, strains with high genetic similarity to SARS-CoV in the hypervariable N-terminal domain (NTD) and receptor-binding domain (RBD) of the S1 gene, the ORF3 and ORF8 region, respectively, were all discovered in this cave. In addition, we report the first discovery of bat SARSr-CoVs highly similar to human SARS-CoV in ORF3b and in the split ORF8a and 8b. Moreover, SARSr-CoV strains from this cave were more closely related to SARS-CoV in the non-structural protein genes ORF1a and 1b compared with those detected elsewhere. Recombination analysis shows evidence of frequent recombination events within the S gene and around the ORF8 between these SARSr-CoVs. We hypothesize that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs. Cell entry studies demonstrated that three newly identified SARSr-CoVs with different S protein sequences are all able to use human ACE2 as the receptor, further exhibiting the close relationship between strains in this cave and SARS-CoV. This work provides new insights into the origin and evolution of SARS-CoV and highlights the necessity of preparedness for future emergence of SARS-like diseases."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1006698"xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1006698"xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Daszak P."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Daszak P."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Wang L.F."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Wang L.F."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Zhang Y.Z."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Zhang Y.Z."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Yang X.L."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Yang X.L."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Shi Z.L."xsd:string |
| http://purl.uniprot.org/citations/29190287 | http://purl.uniprot.org/core/author | "Shi Z.L."xsd:string |