| http://purl.uniprot.org/citations/29197680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29197680 | http://www.w3.org/2000/01/rdf-schema#comment | "Allogeneic stem cell transplantation (allo-SCT) can be a curative treatment for patients with a hematologic malignancy due to alloreactive T cell responses recognizing minor histocompatibility antigens (MiHA). Yet tumor immune escape mechanisms can cause failure of T cell immunity, leading to relapse. Tumor cells display low expression of costimulatory molecules and can up-regulate coinhibitory molecules that inhibit T cell functionality on ligation with their counter-receptors on the tumor-reactive T cells. The aim of this explorative study was to evaluate immune checkpoint expression profiles on T cell subsets and on cytomegalovirus (CMV)-and/or MiHA-reactive CD8+ T cells of allo-SCT recipients using a 13-color flow cytometry panel, and to correlate these expression patterns to clinical outcomes. MiHA-reactive CD8+ T cells exhibited an early differentiated CD27++/CD28++ phenotype with low KLRG-1 and CD57 expression. These T cells also displayed increased expression of PD-1, TIM-3, and TIGIT compared with total effector memory T cells and CMV-specific CD8+ T cells in healthy donors and allo-SCT recipients. Remarkably, high coexpression of PD-1, TIGIT, and KLRG-1 on MiHA-reactive CD8+ T cells was associated with relapse after allo-SCT. Taken together, these findings indicate that MiHA-specific CD8+ T cells of relapsed patients have a distinctive coinhibitory expression signature compared with patients who stay in remission. This phenotype may serve as a potential monitoring tool in patients. Moreover, these findings suggest that PD-1 and TIGIT play important roles in regulating T cell-mediated tumor control, providing a rationale for immunotherapy with blocking antibodies to treat relapse after allo-SCT."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbmt.2017.11.027"xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Wang R.C."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Jansen J.H."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Kester M."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Falkenburg J.H.F."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Dolstra H."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Maas F."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Berglund S."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Luznik L."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Hobo W."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Schaap N."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Norde W.J."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Woestenenk R."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/author | "Hutten T.J.A."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/name | "Biol Blood Marrow Transplant"xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/pages | "666-677"xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/title | "Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation."xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/29197680 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29197680 |
| http://purl.uniprot.org/citations/29197680 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29197680 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGA4-mappedCitation-29197680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29197680 |
| http://purl.uniprot.org/uniprot/#_A0A0M3M0G7-mappedCitation-29197680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29197680 |