DESCRIBE <http://purl.uniprot.org/citations/29199648>

Subject	Predicate	Object
http://purl.uniprot.org/citations/29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29199648	http://www.w3.org/2000/01/rdf-schema#comment	" Background Osteosarcoma, which is also termed osteogenic sarcoma or osteoma sarcomatosum, is the most common form of bone cancer. Typical osteosarcoma can occur at any age, including in infants, children, and the elderly, but more than half of cases occur in individuals who are 10-20 years old. Objective Here, the objective was to search for protein markers to indicate resistance to cisplatin in osteosarcoma and provide a theoretical basis for the early and accurate use of cisplatin to treat osteosarcoma. Methods Thirty patients with osteosarcoma were selected for the study. Experimental studies on the chemosensitivity of osteosarcoma using an in vitro kit method were performed, and cisplatin-resistant and cisplatin-sensitive osteosarcoma tissues were obtained. A representative sample was chosen to analyze and identify differentially expressed proteins in cisplatin-resistant tissues. Results The osteosarcoma-sensitive tissue was analyzed using 2-D electrophoresis and time-of-flight mass spectrometry. Differently expressed proteins were analyzed by western blotting to identify markers. Cisplatin-resistant and cisplatin-sensitive osteosarcoma tissues were obtained. Five significantly differentially expressed proteins were identified, including ALDOA and PGK1. Conclusions The results indicate that ALDOA and PGK1 might be appropriate markers that can be used when treating osteosarcoma with cisplatin."xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.org/dc/terms/identifier	"doi:10.3233/thc-171038"xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/author	"Zhang S."xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/author	"Liu Y.H."xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/author	"Kuang J.M."xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/author	"Qin Y.P."xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/date	"2018"xsd:gYear
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/name	"Technol Health Care"xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/pages	"145-153"xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/title	"Proteomic investigation of resistance to chemotherapy drugs in osteosarcoma."xsd:string
http://purl.uniprot.org/citations/29199648	http://purl.uniprot.org/core/volume	"26"xsd:string
http://purl.uniprot.org/citations/29199648	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/29199648
http://purl.uniprot.org/citations/29199648	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/29199648
http://purl.uniprot.org/uniprot/#_B4DWQ3-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/#_B4E1H9-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/#_B4DHB3-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/#_B4DHM5-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/#_P00558-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/#_Q16444-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/#_V9HWF4-mappedCitation-29199648	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/B4DHB3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/B4DWQ3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/B4E1H9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29199648
http://purl.uniprot.org/uniprot/Q16444	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29199648