| http://purl.uniprot.org/citations/29202466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29202466 | http://www.w3.org/2000/01/rdf-schema#comment | "V617F driver mutation of JAK2 is the leading cause of the Philadelphia-chromosome-negative myeloproliferative neoplasms (MPNs). Although thrombosis is a leading cause of mortality and morbidity in MPNs, the mechanisms underlying their pathogenesis are unclear. Here, we identified pleckstrin-2 (Plek2) as a downstream target of the JAK2/STAT5 pathway in erythroid and myeloid cells, and showed that it is upregulated in a JAK2V617F-positive MPN mouse model and in patients with MPNs. Loss of Plek2 ameliorated JAK2V617F-induced myeloproliferative phenotypes including erythrocytosis, neutrophilia, thrombocytosis, and splenomegaly, thereby reverting the widespread vascular occlusions and lethality in JAK2V617F-knockin mice. Additionally, we demonstrated that a reduction in red blood cell mass was the main contributing factor in the reversion of vascular occlusions. Thus, our study identifies Plek2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced MPNs, pointing to Plek2 as a viable target for the treatment of MPNs."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci94518"xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Mei Y."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Schipma M.J."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Crispino J.D."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Sumagin R."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Stein B."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Ji P."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Abrams C.S."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Wen Q.J."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Stalker T."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/author | "Thorsheim C."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/pages | "125-140"xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/title | "Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms."xsd:string |
| http://purl.uniprot.org/citations/29202466 | http://purl.uniprot.org/core/volume | "128"xsd:string |