| http://purl.uniprot.org/citations/29203887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29203887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29203887 | http://www.w3.org/2000/01/rdf-schema#comment | "The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging heart. MiRNA-sequencing of 5 week (young), 12-21 week (adult) and 28-40 week (old) Nfu hearts revealed 23 up-regulated and 18 down-regulated miRNAs with age. MiR-29 family turned out as one of the most up-regulated miRNAs during aging. MiR-29 family increase induces a decrease of known targets like collagens and DNA methyl transferases (DNMTs) paralleled by 5´methyl-cytosine (5mC) level decrease. To further investigate miR-29 family role in the fish heart we generated a transgenic zebrafish model where miR-29 was knocked-down. In this model we found significant morphological and functional cardiac alterations and an impairment of oxygen dependent pathways by transcriptome analysis leading to hypoxic marker up-regulation. To get insights the possible hypoxic regulation of miR-29 family, we exposed human cardiac fibroblasts to 1% O2 levels. In hypoxic condition we found miR-29 down-modulation responsible for the accumulation of collagens and 5mC. Overall, our data suggest that miR-29 family up-regulation might represent an endogenous mechanism aimed at ameliorating the age-dependent cardiac damage leading to hypertrophy and fibrosis."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-16829-w"xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Braun T."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Braun T."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Guenther S."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Guenther S."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Baumgart M."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Baumgart M."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Rossi G."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Rossi G."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Martelli F."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Martelli F."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Gaetano C."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Gaetano C."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Zeiher A.M."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Zeiher A.M."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Heid J."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Heid J."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Farsetti A."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Farsetti A."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Kuenne C."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Kuenne C."xsd:string |
| http://purl.uniprot.org/citations/29203887 | http://purl.uniprot.org/core/author | "Ripa R."xsd:string |