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http://purl.uniprot.org/citations/29208737http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29208737http://www.w3.org/2000/01/rdf-schema#comment"

Objective

IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial, and there is potential confounding from several secondary effects. In this study, we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterized elderly twins.

Design

A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs.

Methods

A clinical examination including a standard oral glucose tolerance test (OGTT) and anthropometric measurements was performed.

Results

The heritability estimates were high for IGF-I and IGFBP-3 (h2: 0.65 (95% CI: 0.55-0.74) and 0.71 (0.48-0.94), respectively) and for insulin secretion (h2 = 0.56, P < 0.0001), whereas the heritability estimates for insulin sensitivity were low (h2 = 0.14, P = 0.11). In a multiple regression analysis (adjusting for age, gender and twin status), there was a negative association between IGF-I and insulin sensitivity (B: -0.13, SE 0.03, P < 0.0001) and IGF-I and disposition index (B: -0.05, SE 0.02, P < 0.001) in the entire cohort of 606 twins. The associations between IGF-I and both DI and HOMA-S did not differ between the DZ and MZ twins. Forty-five twin pairs were discordant for T2D, but the discordant twins had similar concentrations of IGF-I or IGFBP-3.

Conclusions

There was a high heritability for IGF-I and IGFBP-3, but a low heritability for insulin secretion and insulin sensitivity in a group of elderly twins. In addition, we found a strong negative relationship between IGF-I and insulin sensitivity, which did not seem to be strongly genetically determined."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.org/dc/terms/identifier"doi:10.1530/eje-17-0754"xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Jensen R.B."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Poulsen P."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Janssen J.A.M.J.L."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Dunger D."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Thankamony A."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Juul A."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Holst K.K."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/author"Scheike T."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/name"Eur J Endocrinol"xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/pages"153-161"xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/title"Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins."xsd:string
http://purl.uniprot.org/citations/29208737http://purl.uniprot.org/core/volume"178"xsd:string
http://purl.uniprot.org/citations/29208737http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29208737
http://purl.uniprot.org/citations/29208737http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29208737
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http://purl.uniprot.org/uniprot/#_P05019-mappedCitation-29208737http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29208737
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