| http://purl.uniprot.org/citations/29212956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29212956 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutrophils contribute to demyelinating autoimmune diseases, yet their phenotype and functions have been elusive to date. Here, we demonstrate that ICAM1 surface expression distinguishes extra-from intravascular neutrophils in the mouse CNS during experimental autoimmune encephalomyelitis (EAE). Transcriptomic analysis of these 2 subpopulations indicated that neutrophils, once extravasated, acquire macrophage-like properties, including the potential for immunostimulation and MHC class II-mediated antigen presentation. In corroboration, super-resolution (3D stimulated emission-depletion [STED]) microscopy revealed neutrophils forming synapses with T and B cells in situ. Further, neutrophils specifically express the aspartic retroviral-like protease ASPRV1, which increases in the CNS during EAE and severe cases of multiple sclerosis. Without ASPRV1, mice immunized with a new B cell-dependent myelin antigen (but not with the traditional myelin oligodendrocyte glycoprotein peptide) develop a chronic phase of EAE that is less severe and even completely fades in many individuals. Therefore, ICAM1+ macrophage-like neutrophils can play both shared and nonredundant roles in autoimmune demyelination, among them perpetuating inflammation via ASPRV1."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.96882"xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Jain R."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Dumas A."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Pelletier M."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Gunzer M."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Poubelle P.E."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Larochelle C."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Vallieres L."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Patenaude A."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Kerfoot S."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Tesfagiorgis Y."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/author | "Whittaker Hawkins R.F."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/pages | "96882"xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/title | "ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis."xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/29212956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29212956 |
| http://purl.uniprot.org/citations/29212956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29212956 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-29212956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29212956 |
| http://purl.uniprot.org/uniprot/#_A0A8D3UE05-mappedCitation-29212956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29212956 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-29212956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29212956 |