| http://purl.uniprot.org/citations/29215009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29215009 | http://www.w3.org/2000/01/rdf-schema#comment | "Replication requires homologous recombination (HR) to stabilize and restart terminally arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps and not necessarily double strand breaks. We used genetic and molecular assays to investigate fork-resection and restart at dysfunctional, unbroken forks in Schizosaccharomyces pombe. Here, we report that fork-resection is a two-step process regulated by the non-homologous end joining factor Ku. An initial resection mediated by MRN-Ctp1 removes Ku from terminally arrested forks, generating ~110 bp sized gaps obligatory for subsequent Exo1-mediated long-range resection and replication restart. The mere lack of Ku impacts the processing of arrested forks, leading to an extensive resection, a reduced recruitment of RPA and Rad51 and a slower fork-restart process. We propose that terminally arrested forks undergo fork reversal, providing a single DNA end for Ku binding. We uncover a role for Ku in regulating end-resection of unbroken forks and in fine-tuning HR-mediated replication restart."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-02144-5"xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Hardy J."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Teixeira-Silva A."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Iraqui I."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Freon K."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Ait Saada A."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Lambert S.A.E."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/author | "Nocente M.C."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/pages | "1982"xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/title | "The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks."xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29215009 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29215009 |
| http://purl.uniprot.org/citations/29215009 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29215009 |
| http://purl.uniprot.org/uniprot/O74986#attribution-182E48BD772C7BCB46C7605E4692FD26 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/P53695#attribution-182E48BD772C7BCB46C7605E4692FD26 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/O94395#attribution-182E48BD772C7BCB46C7605E4692FD26 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/Q9UTJ8#attribution-182E48BD772C7BCB46C7605E4692FD26 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/#_P53695-mappedCitation-29215009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/#_O74986-mappedCitation-29215009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/#_O94395-mappedCitation-29215009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29215009 |
| http://purl.uniprot.org/uniprot/#_Q09683-mappedCitation-29215009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29215009 |