| http://purl.uniprot.org/citations/29217135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29217135 | http://www.w3.org/2000/01/rdf-schema#comment | "Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and in vivo experiments. Levels of miR-145 showed an inverse correlation with thrombus load determined by coagulation variables. MiRNA target prediction tools and in vitro study identified tissue factor (TF) as a target gene for miR-145. The restoration of miR-145 levels in thrombotic animals via in vivo miR-145 mimic delivery resulted in decreased TF level and activity, accompanied by reduced thrombogenesis. MiR-145 levels were also reduced in VT patients and correlated with increased TF levels in patients, thereby, confirming our preclinical findings. Our study identifies a previously undescribed role of miRNA in VT by regulating TF expression. Therefore, restoration of miR-145 levels may serve as a promising therapeutic strategy for management of VT."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2017.11.022"xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Sharma S."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Singh S."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Gupta N."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Prabhakar A."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Tyagi T."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Nair V."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Goel S."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Sahu A."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Kumari B."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Chatterjee T."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Jha P.K."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Ashraf M.Z."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/author | "Singh H.D."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/pages | "175-186"xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/title | "MicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in Venous Thrombosis."xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/29217135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29217135 |
| http://purl.uniprot.org/citations/29217135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29217135 |
| http://purl.uniprot.org/uniprot/#_B2R6M5-mappedCitation-29217135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29217135 |
| http://purl.uniprot.org/uniprot/#_P13726-mappedCitation-29217135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29217135 |