| http://purl.uniprot.org/citations/29217771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29217771 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been long assumed that post-mitotic neurons only utilize the error-prone non-homologous end-joining pathway to repair double-strand breaks (DSBs) associated with oxidative damage to DNA, given the inability of non-replicating neuronal DNA to utilize a sister chromatid template in the less error-prone homologous recombination (HR) repair pathway. However, we and others have found recently that active transcription triggers a replication-independent recombinational repair mechanism in G0/G1 phase of the cell cycle. Here we observed that the HR repair protein RAD52 is recruited to sites of DNA DSBs in terminally differentiated, post-mitotic neurons. This recruitment is dependent on the presence of a nascent mRNA generated during active transcription, providing evidence that an RNA-templated HR repair mechanism exists in non-dividing, terminally differentiated neurons. This recruitment of RAD52 in neurons is decreased by transcription inhibition. Importantly, we found that high concentrations of amyloid β, a toxic protein associated with Alzheimer's disease, inhibits the expression and DNA damage response of RAD52, potentially leading to a defect in the error-free, RNA-templated HR repair mechanism. This study shows a novel RNA-dependent repair mechanism of DSBs in post-mitotic neurons and demonstrates that defects in this pathway may contribute to neuronal genomic instability and consequent neurodegenerative phenotypes such as those seen in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m117.808402"xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Levine A.S."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Lan L."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Wetzel R."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Teng Y."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Liang Z."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Thathiah A."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Kodali R."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Welty S."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Rubio M.E."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Greenamyre J.T."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/author | "Sanders L.H."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/pages | "1353-1362"xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/title | "RAD52 is required for RNA-templated recombination repair in post-mitotic neurons."xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/29217771 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29217771 |
| http://purl.uniprot.org/citations/29217771 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29217771 |
| http://purl.uniprot.org/uniprot/#_D3ZZL1-mappedCitation-29217771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29217771 |
| http://purl.uniprot.org/uniprot/#_A6IL90-mappedCitation-29217771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29217771 |
| http://purl.uniprot.org/uniprot/#_A6IL92-mappedCitation-29217771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29217771 |