| http://purl.uniprot.org/citations/29224722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29224722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29224722 | http://www.w3.org/2000/01/rdf-schema#comment | "NMDA receptors (NMDARs) are a subtype of postsynaptic ionotropic glutamate receptors that function as molecular coincidence detectors, have critical roles in models of learning, and are associated with a variety of neurological and psychiatric disorders. To date, no auxiliary proteins that modify NMDARs have been identified. Here, we report the identification of NRAP-1, an auxiliary protein in C. elegans that modulates NMDAR function. NMDAR-mediated currents were eliminated in nrap-1 mutants, as was NMDA-dependent behavior. We show that reconstitution of NMDA-gated current in Xenopus oocytes, or C. elegans muscle cells, depends on NRAP-1 and that recombinant NRAP-1 can convert silent NMDARs to functional channels. Our data indicate that NRAP-1, secreted from presynaptic neurons, localizes to glutamatergic synapses, where it associates with postsynaptic NMDARs to modify receptor gating. Thus, our studies reveal a novel mechanism for synaptic regulation via pre-synaptic control of NMDAR-mediated synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2017.11.019"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2017.11.019"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Maricq A.V."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Maricq A.V."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Madsen D.M."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Madsen D.M."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Brockie P.J."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Brockie P.J."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Mellem J.E."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Mellem J.E."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Lei N."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/author | "Lei N."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/pages | "1303-1316"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/pages | "1303-1316.e6"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/title | "NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/title | "NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength."xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/29224722 | http://purl.uniprot.org/core/volume | "96"xsd:string |