| http://purl.uniprot.org/citations/29227248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29227248 | http://www.w3.org/2000/01/rdf-schema#comment | "Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3-/-), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3-/- mice also exhibited other circadian abnormalities, including lengthening of the period, impaired entrainment to the light-dark cycle, phase variation in locomotor activities, and aberrant physiological rhythms. Ex vivo suprachiasmatic nucleus slices from Sik3-/- mice exhibited destabilized and desynchronized molecular rhythms among individual neurons. In cultured cells, Sik3-knockdown resulted in abnormal bioluminescence rhythms. Expression levels of PER2, a clock protein, were elevated in Sik3-knockdown cells but down-regulated in Sik3-overexpressing cells, which could be attributed to a phosphorylation-dependent decrease in PER2 protein stability. This was further confirmed by PER2 accumulation in the Sik3-/- fibroblasts and liver. Collectively, SIK3 plays key roles in circadian rhythms by facilitating phosphorylation-dependent PER2 destabilization, either directly or indirectly."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.24779"xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Hirano A."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Miyoshi Y."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Fukada Y."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Yoshitane H."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Matsuda J."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Hayasaka N."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/author | "Tokuda I.T."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/pages | "e24779"xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/title | "Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein."xsd:string |
| http://purl.uniprot.org/citations/29227248 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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