| http://purl.uniprot.org/citations/29227283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29227283 | http://www.w3.org/2000/01/rdf-schema#comment | "SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role for SHARPIN in regulating melanoma growth. We observed that SHARPIN interacted with PRMT5, a type II protein arginine methyltransferase, and increased its multiprotein complex and methyltransferase activity. Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI. Activation of PRMT5 by SHARPIN counteracted PRMT5 inhibition by methylthioadenosine, a substrate of methylthioadenosine phosphorylase, which is codeleted with cyclin-dependent kinase inhibitor 2A (CDKN2A) in approximately 15% of human cancers. Collectively, we identified a LUBAC-independent role for SHARPIN in enhancing PRMT5 activity that contributes to melanomagenesis through the SKI/SOX10 regulatory axis."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci95410"xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Tamiya H."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Iwai K."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Ronai Z.A."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Han J.Y."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Kim H.'"xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Kluger H."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Snipas S.J."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Murao A."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Jilaveanu L."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/author | "Klymenko O."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/pages | "517-530"xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/title | "SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth."xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/29227283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29227283 |
| http://purl.uniprot.org/citations/29227283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29227283 |