| http://purl.uniprot.org/citations/29227928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29227928 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of norovirus infections. A structure-guided approach was utilized in the design of a series of inhibitors of norovirus 3CL protease that embody an oxazolidinone ring as a novel design element for attaining optimal binding interactions. Low micromolar cell-permeable inhibitors that display anti-norovirus activity have been identified. The mechanism of action, mode of binding, and structural rearrangements associated with the interaction of the inhibitors and the enzyme were elucidated using X-ray crystallography."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejmech.2017.12.014"xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Battaile K.P."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Lovell S."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Lushington G.H."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Chang K.O."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Nguyen H.N."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Mehzabeen N."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Groutas W.C."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Rathnayake A.D."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Damalanka V.C."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/author | "Galasiti Kankanamalage A.C."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/name | "Eur J Med Chem"xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/pages | "881-890"xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/title | "Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease."xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://purl.uniprot.org/core/volume | "143"xsd:string |
| http://purl.uniprot.org/citations/29227928 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29227928 |
| http://purl.uniprot.org/citations/29227928 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29227928 |
| http://purl.uniprot.org/uniprot/#_Q83883-mappedCitation-29227928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29227928 |
| http://purl.uniprot.org/uniprot/Q83883 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29227928 |