| http://purl.uniprot.org/citations/29228105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29228105 | http://www.w3.org/2000/01/rdf-schema#comment | "Premature decidual senescence is a contributing factor to preterm birth. Fatty acid amide hydrolase mutant females (Faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (LPS) challenge due to enhanced decidual senescence; this is associated with mitogen-activated protein kinase p38 activation. Previous studies have shown that mechanistic target of rapamycin complex 1 (mTORC1) contributes to decidual senescence and promotes the incidence of preterm birth. In this study, we sought to attenuate premature decidual aging in Faah-/-females by targeting mTORC1 and p38 signaling pathways. Because metformin is known to inhibit mTOR and p38 signaling pathways, Faah-/-females were treated with metformin. These mice had a significantly lower preterm birth incidence with a higher rate of live birth after an LPS challenge on day 16 of pregnancy; metformin treatment did not affect placentation or neonatal birth weight. These results were associated with decreased levels of p38, as well as pS6, a downstream mediator of mTORC1 activity, in day 16 Faah-/-decidual tissues. Since metformin treatment attenuates premature decidual senescence with limited side effects during pregnancy, careful use of this drug may be effective in ameliorating specific adverse pregnancy events."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.org/dc/terms/identifier | "doi:10.1093/biolre/iox164"xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/author | "Dey S.K."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/author | "Bradshaw H.B."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/author | "Leishman E."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/author | "Tavenier A."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/pages | "208-217"xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/title | "Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels."xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/29228105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29228105 |
| http://purl.uniprot.org/citations/29228105 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29228105 |
| http://purl.uniprot.org/uniprot/#_O08914-mappedCitation-29228105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29228105 |
| http://purl.uniprot.org/uniprot/#_Q8BRM1-mappedCitation-29228105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29228105 |
| http://purl.uniprot.org/uniprot/#_Q3UUF0-mappedCitation-29228105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29228105 |
| http://purl.uniprot.org/uniprot/#_Q8C541-mappedCitation-29228105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29228105 |
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| http://purl.uniprot.org/uniprot/Q8BRM1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29228105 |
| http://purl.uniprot.org/uniprot/O08914 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29228105 |
| http://purl.uniprot.org/uniprot/Q8C541 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29228105 |