| http://purl.uniprot.org/citations/29233889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29233889 | http://www.w3.org/2000/01/rdf-schema#comment | "Feedback control is a key mechanism in signal transduction, intimately involved in regulating the outcome of the cellular response. Here, we report a novel mechanism by which PHLDA1, Pleckstrin homology-like domain, family A, member 1, negatively regulates ErbB receptor signaling by inhibition of receptor oligomerization. We have found that the ErbB3 ligand, heregulin, induces PHILDA1 expression in MCF-7 cells. Transcriptionally-induced PHLDA1 protein directly binds to ErbB3, whereas knockdown of PHLDA1 increases complex formation between ErbB3 and ErbB2. To provide insight into the mechanism for our time-course and single-cell experimental observations, we performed a systematic computational search of network topologies of the mathematical models based on receptor dimer-tetramer formation in the ErbB activation processes. Our results indicate that only a model in which PHLDA1 inhibits formation of both dimers and tetramer can explain the experimental data. Predictions made from this model were further validated by single-molecule imaging experiments. Our studies suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m117.778399"xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Sako Y."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Ohki R."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Nagashima T."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Garcia-Munoz A."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Iwamoto K."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Yumoto N."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Magi S."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Kholodenko B.N."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Hiroshima M."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Volinsky N."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Okada-Hatakeyama M."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/author | "Von Kriegsheim A."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/pages | "2206-2218"xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/title | "Transcriptionally inducible Pleckstrin homology-like domain, family A, member 1, attenuates ErbB receptor activity by inhibiting receptor oligomerization."xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/29233889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29233889 |
| http://purl.uniprot.org/citations/29233889 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29233889 |
| http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-29233889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29233889 |