| http://purl.uniprot.org/citations/29234882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29234882 | http://www.w3.org/2000/01/rdf-schema#comment | "Endometriosis is a disease in which endometriotic tissue occurs outside the uterus. Its pathogenesis is still unknown. The most widespread hypothesis claims that ectopic endometrium appears as a result of retrograde menstruation and its insufficient elimination by immunocytes. Some reports have shown expression of non-classical HLA-G molecules on ectopic endometrium. HLA-G is recognized by KIR2DL4, LILRB1 and LILRB2 receptors on natural killer (NK) and other cells. These receptors are polymorphic, which may affect their activity. In this study we investigated whether HLA-G, KIR2DL4, LILRB1 and LILRB2 polymorphisms may influence susceptibility to endometriosis and disease progression. We used polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism (PCR-RFLP) and allelic discrimination methods with TaqMan SNP Genotyping Assays for typing of 276 patients with endometriosis and 314 healthy fertile women. The HLA-G rs1632947:GG genotype was associated with protection against the disease and its severe stages; HLA-G rs1233334:CT protected against progression; LILRB1 rs41308748:AA and LILRB2 rs383369:AG predisposed to the disease and its progression. No effect of KIR2DL4 polymorphism was observed. These results support the role of polymorphisms of HLA-G and its receptors LILRB1 and LILRB2 in susceptibility to endometriosis and its progression."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00438-017-1404-3"xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Wagner M."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Ploski R."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Nowak I."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Kaminski P."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Radwan M."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Wisniewski A."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Kusnierczyk P."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Malinowski A."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Wilczynski J.R."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Jasek M."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Milewski L."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Malejczyk J."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Barcz E."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Radwan P."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Niepieklo-Miniewska W."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Bylinska A."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Roszkowski P."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/author | "Wilczynska K."xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/name | "Mol Genet Genomics"xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/pages | "601-613"xsd:string |
| http://purl.uniprot.org/citations/29234882 | http://purl.uniprot.org/core/title | "The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis."xsd:string |