| http://purl.uniprot.org/citations/29238966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29238966 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen storage disease type Ib (GSD-Ib) is caused by mutations of the glucose-6-phosphate transporter (G6PT) and characterized by disrupted glucose homeostasis, neutropenia, and neutrophil dysfunction. To investigate the role of G6PT in human adipose-derived mesenchymal stem cells (hMSCs), the G6PT gene was mutated by CRISPR/Cas9 technology and single cell-derived G6PT-/- hMSCs were established. G6PT-/- hMSCs have significantly increased cell proliferation but impaired adipogenesis and osteogenesis. These phenotypes are associated with two mechanisms: i) metabolic reprogramming in G6PT-/- hMSCs causing a metabolic shift toward glycolysis rather than oxidative phosphorylation and ii) increased cyclooxygenase-2-derived prostaglandin E2 secretion in G6PT-/- hMSCs. This study demonstrates that G6PT is essential for proliferation and differentiation of MSCs, providing important insights into the GSD-Ib phenotypes."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12939"xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Park B.C."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Lee Y.M."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Park T.S."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Jun H.S."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Weinstein D.A."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/author | "Sim S.W."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/pages | "162-171"xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/title | "Aberrant proliferation and differentiation of glycogen storage disease type Ib mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://purl.uniprot.org/core/volume | "592"xsd:string |
| http://purl.uniprot.org/citations/29238966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29238966 |
| http://purl.uniprot.org/citations/29238966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29238966 |
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