| http://purl.uniprot.org/citations/29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29253505 | http://www.w3.org/2000/01/rdf-schema#comment | "The embryonic aorta produces hematopoietic stem and progenitor cells from a hemogenic endothelium localized in the aortic floor through an endothelial to hematopoietic transition. It has been long proposed that the Bone Morphogenetic Protein (BMP)/Transforming Growth Factor ß (TGFß) signaling pathway was implicated in aortic hematopoiesis but the very nature of the signal was unknown. Here, using thorough expression analysis of the BMP/TGFß signaling pathway members in the endothelial and hematopoietic compartments of the aorta at pre-hematopoietic and hematopoietic stages, we show that the TGFß pathway is preferentially balanced with a prominent role of Alk1/TgfßR2/Smad1 and 5 on both chicken and mouse species. Functional analysis using embryonic stem cells mutated for Acvrl1 revealed an enhanced propensity to produce hematopoietic cells. Collectively, we reveal that TGFß through the Alk1/TgfßR2 receptor axis is acting on endothelial cells to produce hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2017.12.006"xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Richard C."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Raymond K."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Jaffredo T."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Drevon C."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Lebrin F."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Canto P.Y."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Lempereur A."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/author | "Thalgott J."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/pages | "292-303"xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/title | "The TGFbeta pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta."xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://purl.uniprot.org/core/volume | "434"xsd:string |
| http://purl.uniprot.org/citations/29253505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29253505 |
| http://purl.uniprot.org/citations/29253505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29253505 |
| http://purl.uniprot.org/uniprot/#_D3Z7H9-mappedCitation-29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29253505 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29253505 |
| http://purl.uniprot.org/uniprot/#_D3YUY5-mappedCitation-29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29253505 |
| http://purl.uniprot.org/uniprot/#_P70340-mappedCitation-29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29253505 |
| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29253505 |
| http://purl.uniprot.org/uniprot/#_P97454-mappedCitation-29253505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29253505 |