| http://purl.uniprot.org/citations/29262338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29262338 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hippo pathway controls organ size and tissue homeostasis through a kinase cascade leading from the Ste20-like kinase Hpo (MST1/2 in mammals) to the transcriptional coactivator Yki (YAP/TAZ in mammals). Whereas previous studies have uncovered positive and negative regulators of Hpo/MST, how they are integrated to maintain signaling homeostasis remains poorly understood. Here, we identify a self-restricting mechanism whereby autophosphorylation of an unstructured linker in Hpo/MST creates docking sites for the STRIPAK PP2A phosphatase complex to inactivate Hpo/MST. Mutation of the phospho-dependent docking sites in Hpo/MST or deletion of Slmap, the STRIPAK subunit recognizing these docking sites, results in constitutive activation of Hpo/MST in both Drosophila and mammalian cells. In contrast, autophosphorylation of the Hpo/MST linker at distinct sites is known to recruit Mats/MOB1 to facilitate Hippo signaling. Thus, multisite autophosphorylation of Hpo/MST linker provides an evolutionarily conserved built-in molecular platform to maintain signaling homeostasis by coupling antagonistic signaling activities."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.11.076"xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/author | "Lei H."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/author | "Pulgar Prieto K.D."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/pages | "3612-3623"xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/title | "Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex."xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/29262338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29262338 |
| http://purl.uniprot.org/citations/29262338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29262338 |
| http://purl.uniprot.org/uniprot/Q9VM65#attribution-ED836ED26951D9348D0F2ADFDD62A897 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29262338 |
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