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http://purl.uniprot.org/citations/29263268http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29263268http://www.w3.org/2000/01/rdf-schema#comment"The group of highly related avian leukosis viruses (ALVs) in chickens are thought to have evolved from a common retroviral ancestor into six subgroups, A to E and J. These ALV subgroups use diverse cellular proteins encoded by four genetic loci in chickens as receptors to gain entry into host cells. Hosts exposed to ALVs might be under selective pressure to develop resistance to ALV infection. Indeed, resistance alleles have previously been identified in all four receptor loci in chickens. The tvb gene encodes a receptor, which determines the susceptibility of host cells to ALV subgroup B (ALV-B), ALV-D, and ALV-E. Here we describe the identification of two novel alleles of the tvb receptor gene, which possess independent insertions each within exon 4. The insertions resulted in frameshift mutations that reveal a premature stop codon that causes nonsense-mediated decay of the mutant mRNA and the production of truncated Tvb protein. As a result, we observed that the frameshift mutations in the tvb gene significantly lower the binding affinity of the truncated Tvb receptors for the ALV-B, ALV-D, and ALV-E envelope glycoproteins and significantly reduce susceptibility to infection by ALV-B, ALV-D and ALV-E in vitro and in vivo Taken together, these findings suggest that frameshift mutation can be a molecular mechanism of reducing susceptibility to ALV and enhance our understanding of virus-host coevolution.IMPORTANCE Avian leukosis virus (ALV) once caused devastating economic loss to the U.S. poultry industry prior the current eradication schemes in place, and it continues to cause severe calamity to the poultry industry in China and Southeast Asia, where deployment of a complete eradication scheme remains a challenge. The tvb gene encodes the cellular receptor necessary for subgroup B, D, and E ALV infection. Two tvb allelic variants that resulted from frameshift mutations have been identified in this study, which have been shown to have significantly reduced functionality in mediating subgroup B, D, and E ALV infection. Unlike the control of herpesvirus-induced diseases by vaccination, the control of avian leukosis in chickens has relied totally on virus eradication measures and host genetic resistance. This finding enriches the allelic pool of the tvb gene and expands the potential for genetic improvement of ALV resistance in varied chicken populations by selection."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.org/dc/terms/identifier"doi:10.1128/jvi.01770-17"xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Chen W."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Li A."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Lin W."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Ma J."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Zhang H."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Yan Y."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Xie Q."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Dai Z."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/author"Shu D."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/name"J Virol"xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/pages"e01770-17"xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/title"Naturally Occurring Frameshift Mutations in the tvb Receptor Gene Are Responsible for Decreased Susceptibility of Chicken to Infection with Avian Leukosis Virus Subgroups B, D, and E."xsd:string
http://purl.uniprot.org/citations/29263268http://purl.uniprot.org/core/volume"92"xsd:string
http://purl.uniprot.org/citations/29263268http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29263268
http://purl.uniprot.org/citations/29263268http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29263268
http://purl.uniprot.org/uniprot/#_Q9IAR7-mappedCitation-29263268http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29263268
http://purl.uniprot.org/uniprot/#_Q8JFD5-mappedCitation-29263268http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29263268
http://purl.uniprot.org/uniprot/#_Q9PW79-mappedCitation-29263268http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29263268
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