| http://purl.uniprot.org/citations/29265728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29265728 | http://www.w3.org/2000/01/rdf-schema#comment | "While α-actin isoforms predominate in adult striated muscle, skeletal muscle-specific knockouts (KOs) of nonmuscle cytoplasmic βcyto - or γcyto -actin each cause a mild, but progressive myopathy effected by an unknown mechanism. Using transmission electron microscopy, we identified morphological abnormalities in both the mitochondria and the sarcoplasmic reticulum (SR) in aged muscle-specific βcyto - and γcyto -actin KO mice. We found βcyto - and γcyto -actin proteins to be enriched in isolated mitochondrial-associated membrane preparations, which represent the interface between mitochondria and sarco-endoplasmic reticulum important in signaling and mitochondrial dynamics. We also measured significantly elongated and interconnected mitochondrial morphologies associated with a significant decrease in mitochondrial fission events in primary mouse embryonic fibroblasts lacking βcyto - and/or γcyto -actin. Interestingly, mitochondrial respiration in muscle was not measurably affected as oxygen consumption was similar in skeletal muscle fibers from 12 month-old muscle-specific βcyto - and γcyto -actin KO mice. Instead, we found that the maximal rate of relaxation after isometric contraction was significantly slowed in muscles of 12-month-old βcyto - and γcyto -actin muscle-specific KO mice. Our data suggest that impaired Ca2+ re-uptake may presage development of the observed SR morphological changes in aged mice while providing a potential pathological mechanism for the observed myopathy."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.org/dc/terms/identifier | "doi:10.1111/febs.14367"xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "McCourt P."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Thomas D.D."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Ervasti J.M."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Nelson D.M."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Yuen S."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Perrin B.J."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Spangenburg E.E."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Lowe D.A."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Lindsay A."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "O'Rourke A.R."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/author | "Tarpey M.D."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/pages | "481-500"xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/title | "Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms."xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/29265728 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29265728 |
| http://purl.uniprot.org/citations/29265728 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29265728 |
| http://purl.uniprot.org/uniprot/#_E9Q606-mappedCitation-29265728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29265728 |
| http://purl.uniprot.org/uniprot/#_A1E281-mappedCitation-29265728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29265728 |
| http://purl.uniprot.org/uniprot/#_B1ATY1-mappedCitation-29265728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29265728 |
| http://purl.uniprot.org/uniprot/#_B2RRX1-mappedCitation-29265728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29265728 |