| http://purl.uniprot.org/citations/29268097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29268097 | http://www.w3.org/2000/01/rdf-schema#comment | "Altered brain energy homeostasis is a key adaptation occurring in the cocaine-addicted brain, but the effect of cocaine on the fundamental source of energy, mitochondria, is unknown. We demonstrate an increase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in cocaine-dependent individuals. Mdivi-1, a demonstrated fission inhibitor, blunts cocaine seeking and locomotor sensitization, while blocking c-Fos induction and excitatory input onto dopamine receptor-1 (D1) containing NAc medium spiny neurons (MSNs). Drp1 and fission promoting Drp1 are increased in D1-MSNs, consistent with increased smaller mitochondria in D1-MSN dendrites after repeated cocaine. Knockdown of Drp1 in D1-MSNs blocks drug seeking after cocaine self-administration, while enhancing the fission promoting Drp1 enhances seeking after long-term abstinence from cocaine. We demonstrate a role for altered mitochondrial fission in the NAc, during early cocaine abstinence, suggesting potential therapeutic treatment of disrupting mitochondrial fission in cocaine addiction."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2017.11.037"xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Martin J.A."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Evans B."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Das S."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Russo S.J."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Turecki G."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Nam H."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Chandra R."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Dietz D.M."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Iniguez S.D."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Lobo M.K."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Werner C.T."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Mathur B.N."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "McGlincy M."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Golden S.A."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Gancarz A.M."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Konkalmatt P."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Francis T.C."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Engeln M."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Creed M."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Riggs L.M."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Schiefer C."xsd:string |
| http://purl.uniprot.org/citations/29268097 | http://purl.uniprot.org/core/author | "Girven K."xsd:string |