| http://purl.uniprot.org/citations/29268856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29268856 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective To determine the role of miR-139 in the development of hepatocellular carcinoma (HCC) and to preliminarily clarify the underlying mechanism. Methods CCK-8 assay was performed to investigate the effect of miR-139 on HCC cell proliferation. Four databases, TargetScan, MiRanda, Clip-seq and miRDB, in combination with literature review, were used to predict the downstream pathways and specifically the potential targets of miR-139. The predicted targets were then verified by Western blot analysis and luciferase reporter assay. Results CCK-8 assay confirmed that miR-139 suppressed the proliferation of HCC cells. By the comparisons between the four databases and the review of literatures, a total of five genes (ICK, BTG3, DCBLD2, EIF4G2 and HNRNPF) were predicted as potential targets of miR-139. Western blot and luciferase reporter assay validated that miR-139 could directly inhibit the expression of BTG3 in HCC cells. Conclusion miR-139 can repress the proliferation of HCC cells via directly inhibiting the expression of BTG3."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/author | "Bai Q."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/name | "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/pages | "1516-1520"xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/title | "[microRNA-139 suppresses proliferation of hepatocellular carcinoma cells by silencing of B cell translocation gene 3]."xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/29268856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29268856 |
| http://purl.uniprot.org/citations/29268856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29268856 |
| http://purl.uniprot.org/uniprot/#_Q14201-mappedCitation-29268856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29268856 |
| http://purl.uniprot.org/uniprot/#_Q6IAU3-mappedCitation-29268856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29268856 |
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| http://purl.uniprot.org/uniprot/Q9UHB2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29268856 |
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| http://purl.uniprot.org/uniprot/Q6IAU3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29268856 |