| http://purl.uniprot.org/citations/29274779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29274779 | http://www.w3.org/2000/01/rdf-schema#comment | "Information of myeloid lineage-related antigen on hematopoietic stem/progenitor cells (HSPCs) is important to clarify the mechanisms regulating hematopoiesis, as well as for the diagnosis and treatment of myeloid malignancies. We previously reported that special AT-rich sequence binding protein 1 (SATB1), a global chromatin organizer, promotes lymphoid differentiation from HSPCs. To search a novel cell surface molecule discriminating early myeloid and lymphoid differentiation, we performed microarray analyses comparing SATB1-overexpressed HSPCs with mock-transduced HSPCs. The results drew our attention to membrane-spanning 4-domains, subfamily A, member 3 (Ms4a3) as the most downregulated molecule in HSPCs with forced overexpression of SATB1. Ms4a3 expression was undetectable in hematopoietic stem cells, but showed a concomitant increase with progressive myeloid differentiation, whereas not only lymphoid but also megakaryocytic-erythrocytic progenitors were entirely devoid of Ms4a3 expression. Further analysis revealed that a subset of CD34+CD38+CD33+ progenitor population in human adult bone marrow expressed MS4A3, and those MS4A3+ progenitors only produced granulocyte/macrophage colonies, losing erythroid colony- and mixed colony-forming capacity. These results suggest that cell surface expression of MS4A3 is useful to distinguish granulocyte/macrophage lineage-committed progenitors from other lineage-related ones in early human hematopoiesis. In conclusion, MS4A3 is useful to monitor early stage of myeloid differentiation in human hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2017.12.117"xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Ishibashi T."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Satoh Y."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Oritani K."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Kanakura Y."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Doi Y."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Sudo T."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Shibayama H."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Tanimura A."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Hamanaka Y."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Ichii M."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Ezoe S."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/author | "Nagate Y."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/pages | "2338-2343"xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/title | "Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://purl.uniprot.org/core/volume | "495"xsd:string |
| http://purl.uniprot.org/citations/29274779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29274779 |
| http://purl.uniprot.org/citations/29274779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29274779 |
| http://purl.uniprot.org/uniprot/#_Q53ZU3-mappedCitation-29274779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29274779 |