| http://purl.uniprot.org/citations/29284022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29284022 | http://www.w3.org/2000/01/rdf-schema#comment | "Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) or loss of Arabidopsis thaliana PARG1 (poly(ADP-ribose) glycohydrolase) disrupt a subset of plant defenses. In the present study we examined the impact of altered poly(ADP-ribosyl)ation on early gene expression induced by the microbe-associate molecular patterns (MAMPs) flagellin (flg22) and EF-Tu (elf18). Stringent statistical analyses and filtering identified 178 genes having MAMP-induced mRNA abundance patterns that were altered by either PARP inhibitor 3-aminobenzamide (3AB) or PARG1 knockout. From the identified set of 178 genes, over fifty Arabidopsis T-DNA insertion lines were chosen and screened for altered basal defense responses. Subtle alterations in callose deposition and/or seedling growth in response to those MAMPs were observed in knockouts of At3g55630 (FPGS3, a cytosolic folylpolyglutamate synthetase), At5g15660 (containing an F-box domain), At1g47370 (a TIR-X (Toll-Interleukin Receptor domain)), and At5g64060 (a predicted pectin methylesterase inhibitor). Over-represented GO terms for the gene expression study included "innate immune response" for elf18/parg1, highlighting a subset of elf18-activated defense-associated genes whose expression is altered in parg1 plants. The study also allowed a tightly controlled comparison of early mRNA abundance responses to flg22 and elf18 in wild-type Arabidopsis, which revealed many differences. The PARP inhibitor 3-methoxybenzamide (3MB) was also used in the gene expression profiling, but pleiotropic impacts of this inhibitor were observed. This transcriptomics study revealed targets for further dissection of MAMP-induced plant immune responses, impacts of PARP inhibitors, and the molecular mechanisms by which poly(ADP-ribosyl)ation regulates plant responses to MAMPs."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0190268"xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Adams-Phillips L.C."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Smith J.A."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Bent A.F."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Zebell S.G."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Arend K.C."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Keppler B.D."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Briggs A.G."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/author | "Apfelbaum A.A."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/pages | "e0190268"xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/title | "A transcriptomics approach uncovers novel roles for poly(ADP-ribosyl)ation in the basal defense response in Arabidopsis thaliana."xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/29284022 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29284022 |
| http://purl.uniprot.org/citations/29284022 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29284022 |
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