| http://purl.uniprot.org/citations/29288201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29288201 | http://www.w3.org/2000/01/rdf-schema#comment | "CD22 and sialic acid-binding Ig-like lectin (Siglec)-G are members of the Siglec family of inhibitory coreceptors expressed on B cells that participate in enforcement of peripheral B cell tolerance. We have shown previously that when a BCR engages its cognate Ag on a cell surface that also expresses Siglec ligands, B cell Siglecs are recruited to the immunological synapse, resulting in suppression of BCR signaling and B cell apoptosis. Because all cells display sialic acids, and CD22 and Siglec-G have distinct, yet overlapping, specificities for sialic acid-containing glycan ligands, any cell could, in principle, invoke this tolerogenic mechanism for cell surface Ags. However, we show in this article that C57BL/6J mouse RBCs are essentially devoid of CD22 and Siglec-G ligands. As a consequence, RBCs that display a cell surface Ag, membrane-bound hen egg lysozyme, strongly activate Ag-specific B cells. We reasoned that de novo introduction of CD22 ligands in RBCs should abolish B cell activation toward its cognate Ag on the surface of RBCs. Accordingly, we used a glyco-engineering approach wherein synthetic CD22 ligands linked to lipids are inserted into the membrane of RBCs. Indeed, insertion of CD22 ligands into the RBC cell surface strongly inhibited B cell activation, cytokine secretion, and proliferation. These results demonstrate that the lack of Siglec ligands on the surface of murine RBCs permits B cell responses to erythrocyte Ags and show that Siglec-mediated B cell tolerance is restricted to cell types that express glycan ligands for the B cell Siglecs."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1701257"xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/author | "Paulson J.C."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/author | "Macauley M.S."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/author | "Spiller F."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/author | "Nycholat C.M."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/author | "Kikuchi C."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/pages | "949-956"xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/title | "Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens."xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://purl.uniprot.org/core/volume | "200"xsd:string |
| http://purl.uniprot.org/citations/29288201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29288201 |
| http://purl.uniprot.org/citations/29288201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29288201 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ27-mappedCitation-29288201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29288201 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSS3-mappedCitation-29288201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29288201 |
| http://purl.uniprot.org/uniprot/#_A0A087WQV3-mappedCitation-29288201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29288201 |
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| http://purl.uniprot.org/uniprot/#_P35329-mappedCitation-29288201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29288201 |