| http://purl.uniprot.org/citations/29288206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29288206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29288206 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging data highlight the crucial role of enzymes involved in amino acid metabolism in immune cell biology. IL-4-induced gene-1 (IL4I1), a secreted l-phenylalanine oxidase expressed by APCs, has been detected in B cells, yet its immunoregulatory role has only been explored on T cells. In this study, we show that IL4I1 regulates multiple steps in B cell physiology. Indeed, IL4I1 knockout mice exhibit an accelerated B cell egress from the bone marrow, resulting in the accumulation of peripheral follicular B cells. They also present a higher serum level of natural Igs and self-reactive Abs. We also demonstrate that IL4I1 produced by B cells themselves controls the germinal center reaction, plasma cell differentiation, and specific Ab production in response to T dependent Ags, SRBC, and NP-KLH. In vitro, IL4I1-deficient B cells proliferate more efficiently than their wild-type counterparts in response to BCR cross-linking. Moreover, the absence of IL4I1 increases activation of the Syk-Akt-S6kinase signaling pathway and calcium mobilization, and inhibits SHP-1 activity upon BCR engagement, thus supporting that IL4I1 negatively controls BCR-dependent activation. Overall, our study reveals a new perspective on IL4I1 as a key regulator of B cell biology."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1601609"xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1601609"xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Auffray C."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Auffray C."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Rondeau E."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Rondeau E."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Bod L."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Bod L."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Richard Y."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Richard Y."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Bekkat F."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Bekkat F."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Castellano F."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Castellano F."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Douguet L."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Douguet L."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Lengagne R."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Lengagne R."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Molinier-Frenkel V."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Molinier-Frenkel V."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Prevost-Blondel A."xsd:string |
| http://purl.uniprot.org/citations/29288206 | http://purl.uniprot.org/core/author | "Prevost-Blondel A."xsd:string |