| http://purl.uniprot.org/citations/29292734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29292734 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocarditis is an inflammatory disease of the myocardium that causes cardiogenic shock and death. However, endomyocardial biopsy that is, the gold standard for a diagnosis is limited. Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein, which is involved in DNA-based excision repair pathway, and in redox signaling, its changes are observed in various cardiovascular diseases including hypertension and coronary artery disease. We analyzed serum APE1/Ref-1 in experimental murine myocarditis. To induce myocarditis, coxsackievirus B3 was injected intraperitoneally to BALB/c mice. The serum APE1/Ref-1, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and troponin I were measured. The histology and virus titers measurements were performed. The troponin I and inflammation were significantly elevated at day 3, peaked to day 7 and decreased at day 10. The NT-proBNP and virus titers were significantly peaked at day 3, and dropped at day 7 and 10. The serum APE1/Ref-1 was gradually raised and its elevation is still maintained until a later time, namely day 10. Also, its level was positively correlated with myocardial inflammation, reflecting severity of myocardial injury. We suggest that serum APE1/Ref-1 can be used to assess for myocardial injury in viral myocarditis without endomyocardial biopsy."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms18122664"xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Seo H.J."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Lim B.K."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Jeon B.H."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Jeong J.O."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Jin S.A."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/author | "Ahn K.T."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/pages | "E2664"xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/title | "Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis."xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/29292734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29292734 |
| http://purl.uniprot.org/citations/29292734 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29292734 |
| http://purl.uniprot.org/uniprot/#_P28352-mappedCitation-29292734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29292734 |
| http://purl.uniprot.org/uniprot/#_Q544Z7-mappedCitation-29292734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29292734 |
| http://purl.uniprot.org/uniprot/P28352 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29292734 |
| http://purl.uniprot.org/uniprot/Q544Z7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29292734 |