| http://purl.uniprot.org/citations/29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29297752 | http://www.w3.org/2000/01/rdf-schema#comment | "Allergic asthma is a common airway inflammatory disease in which B cells play important roles through IgE production and antigen presentation. SNP (single nucleotide polymorphism) analysis showed that Atg (autophagy-related) allele mutations are involved in asthma. It has been demonstrated that macroautophagy/autophagy is essential for B cell survival, plasma cell differentiation and immunological memory maintenance. However, whether B cell autophagy participates in asthma pathogenesis remains to be investigated. In this report, we found that autophagy was enhanced in pulmonary B cells from asthma-prone mice. Autophagy deficiency in B cells led to attenuated immunopathological symptoms in asthma-prone mice. Further investigation showed that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro, which further sustained B cell survival and enhanced antigen presentation by B cells. Moreover, IL4-induced autophagy depended on JAK signaling via an MTOR-independent, PtdIns3K-dependent pathway. Together, our data indicate that B cell autophagy aggravates experimental asthma through multiple mechanisms."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.org/dc/terms/identifier | "doi:10.1080/15548627.2017.1421884"xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Cai Z."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Deng J."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Deng C."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Qu Y."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/author | "Xia F."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/name | "Autophagy"xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/pages | "450-464"xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/title | "IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma."xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/29297752 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29297752 |
| http://purl.uniprot.org/citations/29297752 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29297752 |
| http://purl.uniprot.org/uniprot/#_E9QAM0-mappedCitation-29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29297752 |
| http://purl.uniprot.org/uniprot/#_D4HNR6-mappedCitation-29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29297752 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29297752 |
| http://purl.uniprot.org/uniprot/#_A0A385JBX3-mappedCitation-29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29297752 |
| http://purl.uniprot.org/uniprot/#_F7C090-mappedCitation-29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29297752 |
| http://purl.uniprot.org/uniprot/#_F7CVL9-mappedCitation-29297752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29297752 |