| http://purl.uniprot.org/citations/29298866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29298866 | http://www.w3.org/2000/01/rdf-schema#comment | "Molecular checkpoints that trigger the onset of islet autoimmunity or progression to human type 1 diabetes (T1D) are incompletely understood. Using T cells from children at an early stage of islet autoimmunity without clinical T1D, we find that a microRNA181a (miRNA181a)-mediated increase in signal strength of stimulation and costimulation links nuclear factor of activated T cells 5 (NFAT5) with impaired tolerance induction and autoimmune activation. We show that enhancing miRNA181a activity increases NFAT5 expression while inhibiting FOXP3+ regulatory T cell (Treg) induction in vitro. Accordingly, Treg induction is improved using T cells from NFAT5 knockout (NFAT5ko) animals, whereas altering miRNA181a activity does not affect Treg induction in NFAT5ko T cells. Moreover, high costimulatory signals result in phosphoinositide 3-kinase (PI3K)-mediated NFAT5, which interferes with FoxP3+ Treg induction. Blocking miRNA181a or NFAT5 increases Treg induction in murine and humanized models and reduces murine islet autoimmunity in vivo. These findings suggest targeting miRNA181a and/or NFAT5 signaling for the development of innovative personalized medicines to limit islet autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.org/dc/terms/identifier | "doi:10.1126/scitranslmed.aag1782"xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Becker M."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Nikolaev A."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Kaestner K.H."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Segars J."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Kuper C."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Haase B."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Palmisano R."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Weigmann B."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Kalin S."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Daniel C."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Gerlach K."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Achenbach P."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Schug J."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Ziegler A.G."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Willis R.A."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Kim W.U."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Lehr C.M."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Scherm M.G."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Serr I."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Kirchner B."xsd:string |
| http://purl.uniprot.org/citations/29298866 | http://purl.uniprot.org/core/author | "Loretz B."xsd:string |