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http://purl.uniprot.org/citations/29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29302031http://www.w3.org/2000/01/rdf-schema#comment"Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML. Mechanistically, we show that Pml regulates pro-inflammatory cytokines within MSCs, and that this function is critical in sustaining CML-KLS and AML ckit+ leukemic cells non-cell autonomously."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.org/dc/terms/identifier"doi:10.1038/s41467-017-02427-x"xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Ito K."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Pandolfi P.P."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Fung J."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Mendez L.M."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Berry K."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Asada N."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Frenette P.S."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Menon A.V."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/author"Guarnerio J."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/name"Nat Commun"xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/pages"66"xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/title"A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche."xsd:string
http://purl.uniprot.org/citations/29302031http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/29302031http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29302031
http://purl.uniprot.org/citations/29302031http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29302031
http://purl.uniprot.org/uniprot/#_A0A068EW80-mappedCitation-29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29302031
http://purl.uniprot.org/uniprot/#_D3YXR5-mappedCitation-29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29302031
http://purl.uniprot.org/uniprot/#_F6XUT1-mappedCitation-29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29302031
http://purl.uniprot.org/uniprot/#_D3Z2V0-mappedCitation-29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29302031
http://purl.uniprot.org/uniprot/#_D3Z3A6-mappedCitation-29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29302031
http://purl.uniprot.org/uniprot/#_D6RII9-mappedCitation-29302031http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29302031